Sree Chitra Tirunal Institute for Medical Sciences & Technology, Trivandrum

Mentoring for COVID 19 testing :an exercise in teaching from a National Institute See

Scaffold for liver tissue engineering: Exploring the potential of fibrin incorporated alginate dialdehyde-gelatin hydrogel. See

Introduction Development of a tissue-engineered construct for hepatic regeneration remains a challenging task due to the lack of an optimum environment that support the growth of hepatocytes. Hydrogel systems possess many similarities with tissues and have the potential to provide the ...

Using opensource data to explore distribution of built environment characteristics across Kerala, India See

Background: Built environment characteristics in the neighborhood are of utmost priority for a healthy lifestyle in the fast-urbanizing countries. These characteristics are closely linked to the disease burden and challenges in low- and middle-income countries (LMICs), which have been unexplored ...

Containing the first outbreak of COVID-19 in a healthcare setting in India: The sree chitra experience See

The response to the first health worker case in India and novel strategies adopted in the context of evolving pandemic of COVID-19 is presented here. On the same day of confirmation, institutional COVID cell was established, and contact tracing was started. A total of 184 ...

Vanadium pentoxide nanoparticle mediated perturbations in cellular redox balance and the paradigm of autophagy to apoptosis See

The redox-active transition metals such as copper, iron, chromium, vanadium, and silica are known for its ROS generation via mechanisms such as Haber-Weiss and Fenton-type reactions. Nanoparticles of these metals induce oxidative stress due to acellular factors owing to their small size ...

In vitro and In vivo toxicity analysis of zinc selenium/zinc sulfide (ZnSe/ ZnS) quantum dots See

Despite the versatility of quantum dots (QDs) in optoelectronics and biomedical field, their toxicity risks remain a considerable hindrance for clinical applications. Cytotoxicity of Cadmium containing QDs is well documented and reveals that they are toxic to cells. Reports suggest that the&...

Glial Cell Colony Injured on Exposure to Fullerene Soot Nanoparticles See

An expansion in the field of nanotechnology and their applications in medicine and pharmaceuticals have revolutionized the 20th century. Principally it deals with particles exhibiting a size below 100nm at least in a single dimension. Various fields that gain application potentials&#x...

Water dispersible ZnSe/ZnS quantum dots: Assessment of cellular integration, toxicity and bio-distribution See

Quantum dots (QDs) comprise an emerging group of materials with innumerable number of possibilities in biological research including cellular labelling. Among the leading members in this category, ZnSe/ZnS quantum dots (QDs) hold greater attractive possibilities in imaging primarily due to t...

Formulation and Characterization of Alginate Dialdehyde, Gelatin and Platelet Rich Plasma Based Bioink for Bioprinting See

Layer-by-layer additive manufacturing process has evolved into three-dimensional (3D) “bio-printing” as a means of constructing cell-laden functional tissue equivalents. The process typically involves the mixing of cells of interest with an appropriate hydrogel, termed as “bioink”, followed by printing...

Dextran stabilized fullerene soot induced toxicity on alveolar epithelial cells (A549 cells) See

Fullerene comprises the major allotrope of carbon holding several fruitful potentials to be applied in various industrial and biomedical scenarios. Scientists have acquired large number of data on fullerene research using its derivatives like C60, C70 etc. Nevertheless, a precise focus on&#x...

Nano Fullerene Mixture Impose Threat to Alveolar Epithelial Cells See

Fullerenes, the symmetric allotrope of carbon with bucky ball structure is gaining high magnitude of interest in material chemistry as well as in medical scheme. Fullerenes find its role in batteries, solar cells, for hydrogen storage, trapping reactive species, as lubricants, MRI contr...

A preliminary study on monocyte-platelet interactions in diabetic subjects leading to phenotypic changes in monocytes See

Background and objectives: Platelets become hyperactive during progression of inflammatory disease conditions such as diabetes mellitus. We aimed to assess whether activated platelets (CD62+) interact with monocytes to form monocyteplatelet aggregates and such aggregates change the phenotype of monoc...

Chitra Disinfection Gateway for the Management of COVID 19 in Public Entry Places See

Chitra Disinfection Gateway is meant for the decontamination of personnel entering a cleaner private space from a public space. This is equipped with an arrangement for generating hydrogen peroxide mist and ultraviolet rays. Hydrogen peroxide mist will decontaminate clothes, hands and the&#x...

Fabrication of co-cultured tissue constructs using a dual cell seeding compatible cell culture insert with a clip-on scaffold for potential regenerative medicine and toxicological screening application See

Tissue engineering is emerging as a modern medicine fascination towards the establishment of human tissue banks; yet, these approaches typically involve cultures of only one type of cell and, therefore, do not recapitulate the native tissue physiology in toto. Co-culture models, comprised&#x...

Chitra Ultraviolet C Based Facemask Disposal Bin See

Used face masks are hazardous waste and must be discarded immediately upon removal. Instead of throwing used masks into the disposal bin, disinfecting the masks is essential to break the chain of infection spread. The development of this device was attempted for COVID-19 management...

TTK Chitra tilting disc heart valve model TC2: An assessment of fatigue life and durability See

Average age group of heart valve replacement in India and most of the Third World countries is below 30 years. Hence, the valve for such patients need to be designed to have a service life of 50 years or more which corresponds to 2000 million cycles of operation...

Effects of Yoga on Motor Cortex plasticity, Motor Learning and Motor Deficits of Parkinson’s disease See

Generation of niche tuned antifibrotic fibroblasts and non-viral mediated endothelial commitment using adipose stem cells for dermal graft development See

Cell‐based skin substitute generation has seen considerable development. Combining synthetic scaffolds with biomimetic fibrin does direct both exogenous and endogenous stem cell differentiation, addressing needs for reliable tissue engineering. However, lack of immediate vasculature within implantable grafts re...

Human-Derived Scaffold Components and Stem Cells Creating Immunocompatible Dermal Tissue Ensuing Regulated Nonfibrotic Cellular Phenotypes See

Regeneration of large-sized acute and chronic wounds provoked by severe burns and diabetes is a major concern worldwide. The availability of immunocompatible matrix with a wide range of regenerative medical applications, more specifically, for nonhealing chronic wounds is an unmet clinical n...