Sree Chitra Tirunal Institute for Medical Sciences & Technology, Trivandrum

In magnetic resonance imaging (MRI), gadolinium (Gd) complexes are very often used as contrast agents to enhance the signal from soft tissue deformities and vascular anomalies, to improve the accuracy of diagnosis. The safety concern of using Gd complexes in renally compromised patients...

Organelle targeted photosensitizers (PSs) having luminescence properties are potential theranostic agents for simultaneous luminescence imaging and photodynamic therapy. Herein, we report a water soluble luminescent cyclometalated Ir(III) complex, Ir-Bp-Ly as lysosome targeted theranostic probe. Ir-Bp-...

Background: Hypertension is a major risk factor for cardiovascular disease, a leading cause of premature death and disability in India. Since access to health services is poor in rural India and Accredited Social Health Activists (ASHAs) are available throughout India for materna...

Abstract: Background: The urge for the development and manufacture of new and effective antimicrobial agents is particularly demanding especially in the present scenario of emerging multiple drug resistant microorganisms. A promising initiative would be to converge nanotechnology to develop...

Background & objectives: Polyethylene terephthalate (PET) graft, designed and developed at our institute for vascular reconstruction, is porous to promote optimal incorporation and neointima formation, requiring pre-clotting or biomodification by sealing the pores before implantation. The objec...

The release of corrosion debris from metallic implants leading to adverse tissue reactions and pain has jeopardized the lives of patients. This study attempts to observe if this holds true for widely used cost efficient stainless steel fracture plates and screws by studying&...

Nanoparticles (NPs) are the particles that exist on a nanometer scale i.e. at least one dimension must be below 100 nm. Due to smaller size, they are highly reactive and show exceptional physical, chemical and optical properties compared to the bulk materials. These rem...

The cerebellum can influence the responsiveness of the primary motor cortex (M1) to undergo spike timing-dependent plastic changes through a complex mechanism involving multiple relays in the cerebello-thalamo-cortical pathway. Previous TMS studies showed that cerebellar cortex excitation can block th...

Osteoporotic fracture healing is an orthopaedic challenge due to excessive bone resorption and impaired osteogenesis. Majority of currenttreatment strategies focus on regulating bone resorption and the potential application of Mesenchymal Stem Cells (MSCs) in promoting osteogenesis has not been...

Background: Little research in low and middle-income countries has been conducted on shifts in levels of smoking among those suffering from chronic diseases exposed to cessation messages. We present data on such shifts among diabetes patients participating in a randomized controlled&#...

Background: Central line associated Blood stream infection(CLA-BSI) is a hospital acquired infection that is often missed. In a patient on a central line, culture of peripheral blood along with a sample of blood taken through the CL or CL tips is imperative, for a ...

Background: Type 2 diabetes mellitus (T2DM) is now one of the leading causes of disease-related deaths globally. India has the world’s second largest number of individuals living with diabetes. Lifestyle change has been proven to be an effective means by which to reduce ...

Bio-inspired scaffolds in bone tissue engineering using multipotential mesenchymal stem cells grow at a rapidrate foundits successfuluse inorthopedic injury treatment. Poly(-caprolactone)/PCL is widelyused in medical devices, tissue engineering, and drug delivery systems. Most desirable property of ...