Sree Chitra Tirunal Institute for Medical Sciences & Technology, Trivandrum

Futuristic appplications of multi-organ-on-achip/human-on-a-Chip in biomedical science See

Content validity of the newly developed risk assessment tool for religious mass gathering events in Indian settings (Mass Gathering Risk Assessment Tool-MGRAT). See

Background: Risk assessment (RA) for mass gathering events is crucial to identify potential health hazards. It aids in planning and response activities specific to the event but is often overlooked by the event organizers. This paper reports the content validity process of a newly&...

Strategies to tune electrospun scaffold porosity for effective cell response in tissue engineering See

Tissue engineering aims to develop artificial human tissues by culturing cells on a scaffold in the presence of biochemical cues. Properties of scaffold such as architecture and composition highly influence the overall cell response. Electrospinning has emerged as one of the most afford...

Zinc oxide nanoparticle induced neurotoxic potential upon interaction with primary astrocytes See

As obvious from the basic prerequisite of any particle in nanoscale, Zinc oxide nanoparticles (ZnO NPs) possess numerous tunable properties distinct from their bulk formulations. Emerging innovations in various sectors of nanotechnology are exploiting ZnO NPs largely. This inturn picks up th...

Protocol for development of a risk assessment tool for planning and management of religious mass-gathering events of India-a health system-strengthening initiative See

Background Religious mass gatherings (MGs) have always been an integral part of our society. At the outset, mass-gathering events provide challenging settings to plan a suitable emergency public health response. Published studies basically talk about retrospective reviews, case studies of t...

Reinforcement of amniotic membrane with fibrin coated poly- [Lactide-co-Glycolide-co-Caprolactone] terpolymer containing silver nanoparticles for potential wound healing applications See

Human amniotic membrane (AM) is reported to possess remarkable therapeutic potential for wound healing due to its inherent bioactive and biocompatible properties. However, poor handling characteristics have limited its clinical use on wounds to a great extent. Reinforcement of AM with a ...

Role of phenotypic testing in determining the mechanism of resistance in Gram-negative bacilli & risk factors for meropenem resistance See

Development of calcium sulfate based injectable bone substitute See

The objective of the work is to develop a bone substitute product based on calcium sulfate for filling voids in bone surgeries. The product will be a self-setting, injectable material which is bioactive and safe for human use, with clinically acceptable setting time&#x...

Self-Controlled Hyperthermia & MRI Contrast Enhancement via Iron Oxide Embedded Hydroxyapatite Superparamagnetic particles for Theranostic Application See

Increasing effectiveness of cancer therapeutics requires a multipronged approach. Delivery of controlled hyperthermia in the ranges of 43 to 45 °C on site aided by superparamagnetic particles ensures cell death via the apoptosis pathway.We demonstrated the use of iron-oxide embedded hydroxyapatit...

Comprehensive biology of antipyretic pathways See

Pyrogens, the fever inducing substances accidently enter into a human body through contamination from medical or pharmaceutical products may create mild to severe complications including septicaemia and shocking syndromes. To avoid such drastic situations all the pharmaceuticals and medical devices&#x...

Green synthesis of Pluronic stabilized reduced graphene oxide: Chemical and biological characterization. See

The wonder material graphene has numerous potential applications in nanoelectronics, biomedicine, storage devices, etc. Synthesis of graphene is highly challenging due to the toxic chemicals used and its low yield. In the present study, a facile green route for synthesis of reduced grap...

Cytoskeletal synchronization of CHO cells with polymer functionalized fullerene C60 See

Recent developments in the field of fullerene C60 and its derivatives suggest its suitability in a wide range of applications ranging from photovoltaic instruments, development of solar based cells, cosmetics to enzyme inhibition treatment, and so on. These innovative applications raised pos...

Global, regional, and national burden of neurological disorders, 1990- 2016: a systematic analysis for the Global Burden of Disease Study 2016 See

Background Seizures and their consequences contribute to the burden of epilepsy because they can cause health loss (premature mortality and residual disability). Data on the burden of epilepsy are needed for health-care planning and resource allocation. The aim of this study was t...

Levels of physical inactivity in rural and urban Tamil Nadu, India: A cross-sectional study See

Background and Objectives: Physical inactivity is an important cardiovascular risk factor. This study assessed the prevalence and factors associated with insufficient physical activity (PA) in urban and rural Vellore, Tamil Nadu, India, among adults aged 30–64 years. Methodology: A cross-sectional...

Intracluster correlation estimates from a World Health Organisation STEPwise approach to surveillance (STEPS) survey for cardiovascular risk factors in Vellore, Tamil Nadu, India. Oommen AM1, Mini GK2, George K3. See

OBJECTIVES: Most World Health Organisation (WHO) STEPS surveys use cluster sampling to assess the prevalence of risk factors for non-communicable diseases (NCDs) for which design effects need to be estimated using intracluster correlation (ICCs) coefficients, for sample size calculation. Althoug...

Gender differences and barriers women face in relation to accessing type 2 diabetes care: A systematic review See

The objectives of this systematic review were to find out whether gender differences exist in the domain of access to type 2 diabetes care and to identify the barriers faced by women in accessing type 2 diabetes care. A PubMed search was conducted for English articles...

Bio-interactions and risks of engineered nanoparticles See

Nano technological research offered uncountable opportunities for engineered nanoparticles (ENPs) in the field of biomedical, pharmaceutical, agricultural, cosmetics, textiles, automobiles and electronic industry. Large scale commercial production and use of nanoparticles with smaller size and characteristic physico...

A Simple Method to Efficiently Record/ Capture Caenorhabditis elegans Locomotory Behaviours See

Caenorhabditis elegans is an excellent model to study animal chemotaxis and thermotaxis behaviours. These nematodes have highly predictable behaviour pattern towards olfactory cues. A complex chemosensory information processing, based on both temporal and spacial cues, is involved in chemotaxis behavi...

Intraarticular injection of allogenic chondroprogenitors for treatment of osteoarthritis in rabbit knee model See