SCTIMST DSpace
Digital repository of Sree Chitra Tirunal Institute for Medical Sciences and Technology(SCTIMST), Trivandrum.
This repository is for SCTIMST's research, including project reports, theses, publications and more...
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- Academic Presentations by various Departments and Divisions
Recent Submissions
Data Science for Public Health: Journey of a PhD Scholar
(SCTIMST, 2024-04-20) Arun Mitra, Peddireddy
Overview: Data Science has opened new avenues for addressing complex public health problems and demonstrated that it can drive significant improvements in health services and policy-making. This presentation outlines my journey as a PhD scholar at the Achutha Menon Centre for Health Science Studies (AMCHSS) and my transition from public health to data science. The presentation will showcase some of the key projects including (a) AMCHSS COVID-19 Dashboard, (b) ICMR National COVID-19 Testing Database Project, (c) Trends in Caesarean Sections, (d) Disease Classification using Retinal Images, (e) Access to Stroke Facilities in India, and (f) Capacity Building in Public Health Data Science. The presentation will end with a brief overview of my PhD thesis on improving Maternal and Child Health services in tribal communities, illustrating both the challenges faced and learnings about the potential of data science to transform public health landscapes, particularly among Funderserved communities.
Migration and Health: A public health priority
(SCTIMST, 2024-04-20) Tijo, George
Overview: Migration and health are now recognised as a global public health priority. The Sustainable Development Goals (SDGs) identify migration's pivotal role in achieving their promise of ‘to leave no one behind’. Internal migration is far more than international migration; in a country like India, sometimes the distance and cultures they transit may be more than international migration elsewhere. Thanks to COVID-19, we know how complex the migration nexus is in India. Additionally, India has a shortage of data addressing migration and health. So, during my PhD journey, I have been exploring the migration and health data in the Census and other large-scale surveys like the National Family Health Survey (NFHS) and the Longitudinal Ageing Survey in India (LASI). This presentation will take you through a few papers published and work in progress regarding migration, particularly migration and health.
Utility of interphase fluorescent in situ hybridization for diagnosis of brain tumors
(SCTIMST, 2024-04-06) Deepti, AN
Brain tumours are classified as per the 5th edition of the WHO classification of tumours of the central nervous system. This latest edition of CNS tumors incorporates molecular features along with the conventional histology leading to “histomolecular” classification.
Interphase Fluorescent in situ hybridization (iFISH) is a useful ancillary technique to the pathologist. It is useful to identify gene deletions, amplifications and rearrangements. Fluorescent-tagged FISH probes are hybridized to formalin-fixed paraffin-embedded sections on glass slides and the nuclei are observed under a fluorescent microscope. iFISH is particularly useful in a resource constrained setting where more advanced aids such as methylation profiling and targeted panels are not readily available.
The iFISH technique performed in the pathology department will be discussed and the utility of iFISH in neuro-oncology diagnostics will be illustrated through a case-based discussion.
Epilepsy-associated lesions: Surgical Pathology
(SCTIMST, 2024-04-06) Rajalakshmi, P
Epilepsy is a complex disease and is caused by a variety of lesions that fall under various aetiologies such as malformative, genetic, infectious, metabolic, immune-mediated and neoplastic aetiologies. Patients’ evaluation and management require an interdisciplinary approach with the involvement of clinical assessment, electrophysiology, imaging and pathology. Definitive surgeries are offered to patients with poor response to anti-seizure medications and to those with a focal lesion.
As Pathologists, we receive tissue samples from surgical resections of the epileptogenic focus. The most common lesions that are diagnosed histopathologically are hippocampal sclerosis, focal cortical dysplasias and neoplasms. This talk will give an overview of the various lesions that a neuropathologist encounters in the surgical samples of epilepsy-related disorders. How the samples are processed and assessed will be illustrated.
3D printed arrowroot starch-gellan scaffolds for wound healing applications
(International Journal of Biological Macromolecules, 2024-03) Abey, J; Fathah, M; Athira, SV; Joseph, X; Megha, KB; Akash, K; Nigina, G; Mohanan, PV; Baiju, GN
Skin, the largest organ in the body, blocks the entry of environmental pollutants into the system. Any injury to this organ allows infections and other harmful substances into the body. 3D bioprinting, a state-of-the-art technique, is suitable for fabricating cell culture scaffolds to heal chronic wounds rapidly. This study uses starch extracted from Maranta arundinacea (Arrowroot plant) (AS) and gellan gum (GG) to develop a bioink for 3D printing a scaffold capable of hosting animal cells. Field emission scanning electron microscopy (FE-SEM) and X-ray diffraction analysis (XRD) prove that the isolated AS is analogous to commercial starch. The cell culture scaffolds developed are superior to the existing monolayer culture. Infrared microscopy shows the AS-GG interaction and elucidates the mechanism of hydrogel formation. The physicochemical properties of the 3D-printed scaffold are analyzed to check the cell adhesion and growth; SEM images have confirmed that the AS-GG printed scaffold can support cell growth and proliferation, and the MTT assay shows good cell viability. Cell behavioral and migration studies reveal that cells are healthy. Since the scaffold is biocompatible, it can be 3D printed to any shape and structure and will biodegrade in the requisite time.