Please use this identifier to cite or link to this item: http://dspace.sctimst.ac.in/jspui/handle/123456789/1008
Title: Role of immune cells and inflammatory cytokines in regulation of fibrosis around silicone expander implants
Authors: Joseph, Josna
Mohanty, Mira
Mohanan, PV
Keywords: Biocompatibility
Issue Date: 2010
Publisher: JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE
Citation: JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE. 21; 5; 1665-1676
Abstract: This study aimed to investigate the progress of wound healing around silicone expander with particular emphasis on fibroblasts, myofibroblasts and collagen in the repair phase. Semi-quantitative evaluation of inflammatory cells and their cytokines, fibroblasts and myofibroblasts at the tissue-material interface was carried out. Commercially available silicone expander was implanted in gluteus muscle of young female Wistar rats for 3, 7, 14, 30, 90 and 180 days. Ultra high molecular weight polyethylene served as control. The cellular response was studied by immunohistochemistry and Transmission Electron Microscopy. A thick collagenous fibrous capsule was observed around the silicone expander at 180 days, with persistent myofibroblasts, lymphocytes and macrophages as compared to the thin fibrous encapsulation around the UHMWPE implants. The regulatory role of cytokines and immune cells in myofibroblast persistence in tissue-implant interface around silicone expander has been extensively studied. Results of this study indicate the need to elucidate the signaling molecules in the transition of fibroblast to myofibroblast around silicone expander implants.
URI: http://dx.doi.org/10.1007/s10856-010-4015-7
http://www.ncbi.nlm.nih.gov/pubmed/20162333
http://dspace.sctimst.ac.in/jspui/handle/123456789/1008
Appears in Collections:Journal Articles

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