Please use this identifier to cite or link to this item: http://dspace.sctimst.ac.in/jspui/handle/123456789/10105
Title: Nanohydroxyapatite Incorporated Electrospun Polycaprolactone/Polycaprolactone-Polyethyleneglycol-Polycaprolactone Blend Scaffold for Bone Tissue Engineering Applications
Authors: Remya, KR
Joseph, J
Mani, S
John, A
Varma, HK
Ramesh, P
Keywords: Science & Technology - Other Topics; Materials Science
Issue Date: 2013
Publisher: JOURNAL OF BIOMEDICAL NANOTECHNOLOGY
Citation: 9 ,9;1483-1494
Abstract: The present work is a comparative evaluation of physical and biological properties of electrospun biodegradable fibrous scaffolds based on polycaprolactone (PCL) and its blend with polycaprolactone-polyethyleneglycol-polycaprolactone (CEC) with and without nanohydroxyapatite (nHAP) particles. The fiber morphology, porosity, surface wettability, and mechanical properties of electrospun PCL were distinctly influenced by the presence of both copolymer CEC and nHAP. The degradation in hydrolytic media affected both morphological and mechanical properties of the scaffolds and the tensile strength decreased by 58% for PCL, 83% for PCL/CEC, 36% for PCL/nHAP and 75% for PCL/CEC/nHAP in 90 days of PBS ageing. MU assay using mouse fibroblast L929 cells proved all the scaffolds to be non-cytotoxic. An overall enhanced performance was shown by PCL/CEC/nHAP scaffold in cell viability (LDH) and proliferation (Picogreen). Simultaneously, ELF assay of ALP activity (bone marker) confirmed the presence of osteogenic-induced Rabbit adipose-derived mesenchymal stem cells (ADMSCs) on all the scaffolds. In comparison, the results reveal the potential of the cytocompatible PCL/CEC/nHAP scaffold for the fabrication of living bony constructs for tissue engineering applications.
URI: 10.1166/jbn.2013.1640
http://dspace.sctimst.ac.in/jspui/handle/123456789/10105
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