On the application of molecularly imprinted poly(HEMA) as a template responsive release system

Abstract

2-Hydroxy-ethyl-methacrylate-based molecularly imprinted polymer imprinted for hydrocortisone was found to absorb a considerable amount of testosterone. The release of testosterone to water was found to be very slow. Its release was, however, rapid in the presence of the print molecule (hydrocortisone). This opens up the possibility of developing drug release systems capable of modulating the release with respect to the presence of specific molecules. Such systems could be used in the release of steroids and peptides. (C) 1999 John Wiley & Sons, Inc.