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Title: On the development of an apatitic calcium phosphate bone cement
Authors: Komath, M
Varma, HK
Sivakumar, R
Keywords: Materials Science
Issue Date: 2000
Citation: 23 ,2;135-140
Abstract: Development of an apatitic calcium phosphate bone cement is reported. 100 mu Particles of tetracalcium phosphate (TTCP) and dicalcium phosphate dihydrate (DCPD) were mixed in equimolar ratio to form the cement powder. The wetting medium used was distilled water with Na2HPO4 as accelerator to manipulate the setting time. The cement powder, on wetting with the medium, formed a workable putty. The setting times of the putty were measured using a Vicat type apparatus and the compressive strength was determined with a Universal Testing Machine. The nature of the precipitated cement was analyzed through X-ray diffraction (XRD), fourier transform infrared spectrometry (FTIR) and energy dispersive electron microprobe (EDAX). The results shelved the phase to be apatitic with a calcium-to-phosphorous ratio close to that of hydroxyapatite. The microstructure analysis using scanning electron microscopy (SEM) showed hydroxyapatite nanocrystallite growth over particulate matrix surface. The structure has an apparent porosity of similar to 52%. There were no appreciable dimensional or thermal changes during setting. The cement passed the in vitro toxicological screening (cytotoxicity and haemolysis) tests. Optimization of the cement was done by manipulating the accelerator concentration so that the setting time, hardening time and the compressive strength had clinically relevant values.
URI: 10.1007/BF02706555
Appears in Collections:Journal Articles

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