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Title: Poly(epsilon-caprolactone) microspheres as a vaccine carrier
Authors: Jameela, SR
Suma, N
Misra, A
Raghuvanshi, R
Keywords: Science & Technology - Other Topics
Issue Date: 1996
Citation: 70 ,7;669-671
Abstract: Poly(epsilon-caprolactone) (PCL), a biocompatible and biodegradable polymer hitherto thought unsuitable for protein delivery because of its poor permeability to macromolecules, is shown to be sufficiently permeable to proteins to function as a vaccine carrier, Using a model antigen such as bovine serum albumin (BSA), we demonstrate that a single injection of BSA-loaded PCL microspheres generates an immune response comparable in magnitude and time kinetics to that of a conventional three-injection schedule of the antigen in a rat model, Unlike polyesters such as poly(lactic acid) (PLA) and poly(glycolic acid) (PGA), PCL degrades slowly and therefore does not generate an acid environment adversely affecting the antigenicity of vaccines and may prove to be promising as a vaccine carrier.
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