Please use this identifier to cite or link to this item: http://dspace.sctimst.ac.in/jspui/handle/123456789/10252
Title: Polycaprolactone-laponite composite scaffold releasing strontium ranelate for bone tissue engineering applications
Authors: Nair, BP
Sindhu, M
Nair, PD
Keywords: Biophysics; Chemistry; Materials Science
Issue Date: 2016
Publisher: COLLOIDS AND SURFACES B-BIOINTERFACES
Citation: 143 ,;423-430
Abstract: We report polycaprolactone-laponite composite scaffold for the controlled release of strontium ranelate (SRA), a drug for osteoporosis. Laponite-SRA complex with electrostatic interaction between the drug and laponite was obtained through an aqueous phase reaction. Structural evaluation verified complexation of the bulky SRA molecules with the negatively charged laponite tactoid surfaces, leading to extended ordering of the tactoids, leaving behind the interlayer spacing of the laponite unchanged. The laponite-SRA complex was solution blended with polycaprolactone to obtain composite scaffolds. The strategy was found improving the dispersibility of laponite in PCL due to partial organomodification imparted through interaction with the SRA. The composite scaffolds with varying laponite-SRA complex content of 3-12 wt% were evaluated in vitro using human osteosarcoma cells. It was confirmed that an optimum composition of the scaffold with 3 wt% laponite-SRA complex loading would be ideal for obtaining enhanced ALP activity, by maintaining cell viability. (C) 2016 Elsevier B.V. All rights reserved.
URI: 10.1016/j.colsurfb.2016.03.033
http://dspace.sctimst.ac.in/jspui/handle/123456789/10252
Appears in Collections:Journal Articles

Files in This Item:
There are no files associated with this item.


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.