Please use this identifier to cite or link to this item: http://dspace.sctimst.ac.in/jspui/handle/123456789/10259
Title: Polyurethane thermoplastic elastomers with inherent radiopacity for biomedical applications
Authors: Kiran, S
James, NR
Jayakrishnan, A
Joseph, R
Keywords: Engineering; Materials Science
Issue Date: 2012
Publisher: JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
Citation: 100A ,12;3472-3479
Abstract: Synthesis and characterization of three different radiopaque thermoplastic polyurethane elastomers are reported. Radiopacity was introduced to the polyurethanes by incorporating an iodinated chain extender, namely, 4,4'-isopropylidinedi-(2,6-diiodophenol) (IBPA), into the polymer chain during polyurethane synthesis. Radiopaque polyurethanes (RPUs) were synthesized by reacting 4,4'-methylenebis(phenyl isocyanate) (MDI), IBPA, and three different diols. The polyols used for the synthesis were polypropylene glycol, polycaprolactone diol, and poly(hexamethylene carbonate) diol. RPUs were characterized by infrared spectroscopy, contact angle measurements, thermogravimetry, dynamic mechanical analysis, energy dispersive X-ray analysis, gel permeation chromatography, X-ray fluorescence spectroscopy, and X-radiography. X-ray images showed that all RPUs prepared using IBPA as the chain extender are highly radiopaque compared with an Aluminum wedge of equivalent thickness. Elemental analysis revealed that the polyurethanes contained 1819% iodine in the polymer matrix. The RPUs developed have radiopacity equivalent to that of a polymer filled with 20 wt % barium sulfate. Results revealed that RPUs of wide range of properties may be produced by incorporating different diols as the soft chain segment. Cell culture cytotoxicity studies conducted using L929 cells by direct contact test and MTT assay proved that these RPUs are noncytotoxic in nature. (c) 2012 Wiley Periodicals, Inc. J Biomed Mater Res Part A:, 2012.
URI: 10.1002/jbm.a.34295
http://dspace.sctimst.ac.in/jspui/handle/123456789/10259
Appears in Collections:Journal Articles

Files in This Item:
There are no files associated with this item.


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.