Please use this identifier to cite or link to this item: http://dspace.sctimst.ac.in/jspui/handle/123456789/1037
Title: Serum tumour necrosis factor-alpha and soluble tumour necrosis factor receptors levels in patients with Guillain-Barre syndrome
Authors: Radhakrishnan, VV
Sumi, MG
Reuben, S
Mathai, A
Nair, MD
Keywords: Neurology
Issue Date: 2004
Publisher: ACTA NEUROLOGICA SCANDINAVICA
Citation: ACTA NEUROLOGICA SCANDINAVICA. 109; 1; 71-74
Abstract: Objectives - To estimate the serum concentrations of Tumour Necrosis Factor alpha (TNF-alpha) and soluble TNF receptors (s TNF-RI and TNF-RII) in patients with Guillain-Barre syndrome (GBS), before and after treatment. Material and methods - The serum TNF-alpha and the soluble TNF receptors concentrations were measured by a sandwich enzyme-linked immunosorbent assay (ELISA) in 47 patients with GBS before and after the treatment - IVI therapy (n = 26); Plasma Exchange (n = 21). Results- At the time of admission, the serum TNF-alpha concentrations were elevated (32.5-182.5 pg/ml) in 41/47 GBS patients (87.2%). Following the treatment (IVIG or PE), there was a significant decrease in the serum TNF-alpha concentrations (8.5-58.5 pg/ml) in these 41 GBS patients. The soluble TNF receptors, particularly sTNF-RII concentrations were significantly increased in GBS patients treated by IVIG therapy. Conclusions - The results of this indicated that (a) Elevated serum concentrations of TNF-alpha showed a positive correlation with the disease severity in patients with GBS. (b) The decrease in the serum TNF-alpha and increase in the serum soluble TNF receptors, particularly sTNF-RII showed a positive correlation with the neurological recovery in GBB patients following treatment.
URI: http://dx.doi.org/10.1034/j.1600-0404.2003.00179.x
http://www.ncbi.nlm.nih.gov/pubmed/14653854
http://dspace.sctimst.ac.in/jspui/handle/123456789/1037
Appears in Collections:Journal Articles

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