Please use this identifier to cite or link to this item: http://dspace.sctimst.ac.in/jspui/handle/123456789/10477
Title: Studies on Polymerization and Elution Characteristics of Antibiotic Loaded Acrylic Bone Cements
Authors: Lizymol, PP
Krishnan, VK
Keywords: Polymer Science
Issue Date: 2010
Publisher: JOURNAL OF POLYMER MATERIALS
Citation: 27 ,3;257-266
Abstract: Acrylic bone cements are widely used in orthopedic applications for anchoring the prosthesis to the contiguous bone in cemented arthroplasty. Wide spectrum antibiotics such as ampicillin and tetracycline have been incorporated into bone cement and their effect upon polymerization characteristics such as working and setting times have been monitored using cycloviscograph and properties like diametral tensile strength (DTS) evaluated. Antibiotic elution into phosphate buffered saline at different intervals of time was evaluated and compared for both antibiotics. Working and setting times were found to increase with antibiotic concentration in the bone cement. Presence of ampicillin was found to have no effect upon the strength of the bone cement while tetracycline had a deteriorating effect upon DTS. Rate of antibiotic elution into phosphate buffered saline (PBS) was observed to be higher for ampicillin compared to tetracycline. Cytotoxic evaluation of the virgin bone cement did not elicit any toxic response.
URI: http://dspace.sctimst.ac.in/jspui/handle/123456789/10477
Appears in Collections:Journal Articles

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