Please use this identifier to cite or link to this item: http://dspace.sctimst.ac.in/jspui/handle/123456789/10532
Title: Synthesis and characterization of alginate coated zinc calcium phosphate nanoparticles for intestinal delivery of insulin
Authors: Paul, W
Sharma, CP
Keywords: Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology; Engineering
Issue Date: 2012
Publisher: PROCESS BIOCHEMISTRY
Citation: 47 ,5;882-886
Abstract: Nanosized calcium phosphates studied as drug delivery systems are highly compatible with the various drugs like insulin, antibiotics etc. Zinc is an essential trace element that plays a crucial role in the synthesis, storage and release of insulin in a human body. Therefore, an attempt has been made to develop zinc modified calcium phosphate nanoparticles (less than 100 nm) as carriers for intestinal delivery of insulin. The insulin loaded nanoparticles were coated with pH sensitive alginate. These pH sensitive nanoparticles released insulin in the intestinal medium, and the conformation of released insulin was stable. The blood glucose level of diabetic rats came to normal on administration of the formulation. With the beneficial effect of zinc reported on diabetic patients, the present system seems to be an excellent carrier for intestinal delivery of insulin. (C) 2012 Elsevier Ltd. All rights reserved.
URI: 10.1016/j.procbio.2012.01.018
http://dspace.sctimst.ac.in/jspui/handle/123456789/10532
Appears in Collections:Journal Articles

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