Please use this identifier to cite or link to this item: http://dspace.sctimst.ac.in/jspui/handle/123456789/1080
Title: Stimuli sensitive polymethacrylic acid microparticles (PMAA) - Oral insulin delivery
Authors: Victor, SP
Sharma, CP
Keywords: Drug Delivery
Issue Date: 2002
Publisher: JOURNAL OF BIOMATERIALS APPLICATIONS
Citation: JOURNAL OF BIOMATERIALS APPLICATIONS. 17; 2; 125-134
Abstract: This study investigated polymethacrylic acid (PMAA) microparticles for controlled release of Insulin in oral administration. The microparticles were characterised by scanning electron microscopy (SEM) for morphological studies. The swelling behaviour and drug release profile in various pH media were studied. The % swelling of gels was found to be inversely related to the amount of crosslinker added. Inclusion complex of betaCD and Insulin was studied using polyacrylamide gel electrophoresis (PAGE). Optimum complexation was obtained in the ratio 100 mg betaCD: 200IU Insulin. The release pattern of Insulin from Insulin-betaCD complex encapsulated PMAA microparticles showed release of Insulin for more than seven hours.
URI: http://dx.doi.org/10.1106/088532802028583
http://dspace.sctimst.ac.in/jspui/handle/123456789/1080
Appears in Collections:Journal Articles

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