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Title: An electrospun citric acid modified polyvinyl alcohol scaffold for vascular tissue engineering
Authors: Thomas, LV
Nair, PD
Keywords: Electrospun scaffold, poly(vinyl alcohol), citric acid, smooth muscle cells, vascular tissue engineering
Issue Date: May-2019
Publisher: Journal of Bioactive and Compatible Polymers
Citation: Thomas LV, Nair PD. An electrospun citric acid modified polyvinyl alcohol scaffold for vascular tissue engineering. Journal of Bioactive and Compatible Polymers. 2019 May; 34(3): 263-279
Abstract: The main aim of this study is to fabricate an electrospun citric acid modified polyvinyl alcohol polyester that is biodegradable with non-toxic by-products and can be used for the culture of vascular smooth muscle cells. In this study, we have optimized the conditions for the electrospinning process of this polyester. The fibre morphology was studied by scanning electron microscopy which indicated that the fibre diameter was optimum at a range of 200 to 700 µm at 5% concentration and flow rate of 0.3 mL/h. The membranes were characterized for the change in structural aspects at the molecular level. The results showed development of more crystalline domains on electrospinning. The surface characteristics were also explored. Cell culture studies confirmed that the electrospun scaffold supported the attachment and proliferation of smooth muscle cells, which was evident from the cell proliferation assay. Hence, the electrospun polyester scaffolds are non-toxic and biocompatible with vascular smooth muscle cells, and find promising potential as scaffolds for vascular tissue engineering
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