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Title: Toxicity of dextran stabilized fullerene C60 against C6 Glial cells
Authors: Biby, TE
Prajitha, N
Ashtami, J
Sakthikumar, D
Maekawa, T
Mohanan, PV
Keywords: Glial cells; Toxicity; Fullerene C60; Nanoparticles; Dextran
Issue Date: Jan-2020
Publisher: Brain Research Bulletin
Citation: Biby TE, Prajitha N, Ashtami J, Sakthikumar D, Maekawa T, Mohanan PV. Toxicity of dextran stabilized fullerene C60 against C6 Glial cells. Brain Research Bulletin. 2020 Feb;155:191-201
Abstract: Elevated application potential of fullerene C60 paved the way to think on its adverse effect when it reaches to biological system and environment. Though fullerenes are insoluble in water, various strategies are employed to make it soluble. Method of solubilization with organic solvents, yield cytotoxic responses both in vitro and in vivo. In this study, dextran was used to stabilize C60 particle. Fourier transformed-infrared spectroscopy (FT-IR) and transition electron microscopy (TEM) were used for characterization and it confirms effective surface stabilization and morphological characteristics. This was followed by various cytotoxicity studies to evaluate its bio-nano interactions. The results of the study suggest that the dextran stabilized C60 nanoparticles (Dex-C60) forms uniform suspension in water and was stable up to 72 h. The C6 glial cell-Dex-C60 interactions indicated that the Dex-C60 nanoparticles penetrate deeper into the cells and cause dose dependent toxic response. The result of the study recommended that Dex-C60 nanoparticles should undergo intensive risk assessment before biomedical applications and should take proper safety measure to avoid its entry to the environment.
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