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Title: Nano Fullerene Mixture Impose Threat to Alveolar Epithelial Cells
Authors: Athira, SS
Ashtami, J
Mohanan, PV
Keywords: Fullerene; Alveolar Cells; Bucky Ball; Nanoparticles; Safety
Issue Date: Aug-2020
Publisher: Ec Pharmacology And Toxicology
Citation: Athira SS,.Ashtami J, Mohanan PV. Nano Fullerene Mixture Impose Threat to Alveolar Epithelial Cells. Ec Pharmacology And Toxicology. 2020;8.9:38-43
Abstract: Fullerenes, the symmetric allotrope of carbon with bucky ball structure is gaining high magnitude of interest in material chemistry as well as in medical scheme. Fullerenes find its role in batteries, solar cells, for hydrogen storage, trapping reactive species, as lubricants, MRI contrast agents, protective coatings, superconductors and also in biomedical applications as neuroprotective agents, anti-oxidant, enzyme inhibitor, delivery vector, biosensor, for photodynamic therapy etc. Apart from the intentional exposure during usage in various applications, nano fullerene mixture is present in automobile/industrial exhaust, release from incomplete combustion of fossil fuels etc. Increased exposure entail the exigency for toxicity profiling of fullerene. Inhalation being a major route of nanoparticle exposure compels lungs at high risk of toxicity due to accumulation. Retention at the “alveoli site” potentially causes translocation into blood that further complicates the scenario. Improved perception on the effect of nano fullerene mixture on lung cells is needed to make a critical inference.
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