Please use this identifier to cite or link to this item: http://dspace.sctimst.ac.in/jspui/handle/123456789/11066
Title: Nanohybrids of Magnetically Intercalated Optical Metamaterials for Magnetic Resonance/Raman Imaging and In Situ Chemodynamic/Photothermal Therapy
Authors: Jibin, K
Victor, M
Saranya, G
Hema, S
Murali, V
Maiti, KK
Jayasree, RS
Issue Date: Jul-2021
Publisher: ACS Applied Biomaterials
Citation: Jibin K, Victor M, Saranya G, Hema S, Murali V, Maiti KK, Jayasree RS. Nanohybrids of Magnetically Intercalated Optical Metamaterials for Magnetic Resonance/Raman Imaging and In Situ Chemodynamic/Photothermal Therapy. ACS Applied Biomaterials. 2021 Jul; 4(7): 5742–5752
Abstract: Target-specific reactive oxygen species (ROS)-based cancer treatments with high therapeutic efficacy and minimal side effects have been identified recently as a potentially effective cancer management strategy. Herein, we report the fabrication of a targeted nanotheranostic agent built on an iron oxide nanoparticle-decorated graphene–gold hybrid [plasmonic magnetic nanoprobe (PMNP)] for self-guided magnetic resonance (MR)/surface-enhanced Raman scattering imaging and photothermal therapy (PTT)/chemodynamic therapy (CDT). In the presence of glutathione, which is abundant in the tumor environment, the iron oxide nanoparticles undergo in situ reduction, which in turn generates hydroxyl radicals via a Fenton reaction to realize targeted destruction of tumor cells. Moreover, the localized production of heat benefited from the near-infrared absorption of the PMNP accelerates the intratumoral ROS generation process, with a synergistic effect of CDT/PTT. Furthermore, the probe offers an accurate visualization of the intracellular localization of the material through SERS/MR dual imaging channels. In view of the advantages offered by the tumor-specific stimuli-responsive nature of the probe, the PMNP presents as an effective tool for cancer management.
URI: https://doi.org/10.1021/acsabm.1c00510
http://dspace.sctimst.ac.in/jspui/handle/123456789/11066
Appears in Collections:Journal Articles

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