Please use this identifier to cite or link to this item: http://dspace.sctimst.ac.in/jspui/handle/123456789/11072
Title: Extracellular matrix-based combination scaffold for guided regeneration of large-area full-thickness rabbit burn wounds upon a single application
Authors: Ramakrishnan, R
Harikrishnan, VS
Anil, A
Sabareeswaran, A
Krishnan, LK
Issue Date: Nov-2021
Publisher: Journal of Biomedical Material Research Part B Applied Biomaterials
Citation: Ramakrishnan R, Harikrishnan VS, Anil A, Sabareeswaran A, Krishnan LK.Extracellular matrix-based combination scaffold for guided regeneration of large-area full-thickness rabbit burn wounds upon a single application. Journal of Biomedical Material Research Part B Applied Biomaterials. 2021 Nov:1-14.DOI: 10.1002/jbm.b.34965
Abstract: Regeneration of large acute and chronic wounds is a concern worldwide. The present study evaluates wound healing competence of a completely human-origin, extracellular matrix (ECM)-based skin substitute/graft. It comprises cell-less amniotic membrane (AM), clinical-grade fibrin (FIB), and hyaluronic acid (HA) termed as AMFIBHA. The use of large-area third-degree rabbit burn wounds evaluated the product efficiency. The AMFIBHA induces hemostasis and permits suture-less positioning on the wound bed. In wet wounds, the AMFIBHA degrades and release biologically active molecules and guide cell migration, proliferation, and regeneration. The study demonstrated the effectiveness of this wound care product in terms of epithelial-dermal regeneration with angiogenesis. The study assessed injury-associated inflammation and different wound healing markers after 28 days of experiment and compared with both positive and negative controls-treated wounds. The regeneration of mature epidermis and dermis with rete pegs and hair follicle-like structure was evident upon a single application. The active involvement of host cells resulted in supple tissue formation. The ECM organization of AMFIBHA-treated tissue resulted in re-gain of mechanical properties comparable to native skin after 56 days. These guided regenerative outcomes reveal a promising translational value of the novel AMFIBHA skin substitute as an off-the-shelf product for clinical use.
URI: https://doi.org/10.1002/jbm.b.34965
http://dspace.sctimst.ac.in/jspui/handle/123456789/11072
Appears in Collections:Journal Articles

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