Please use this identifier to cite or link to this item: http://dspace.sctimst.ac.in/jspui/handle/123456789/1117
Title: Superoxide-mediated activation of cardiac fibroblasts by serum factors in hypomagnesemia
Authors: Kumaran, C
Shivakumar, K
Keywords: Cardiology
Issue Date: 2001
Publisher: FREE RADICAL BIOLOGY AND MEDICINE
Citation: FREE RADICAL BIOLOGY AND MEDICINE. 31; 7; 882-886
Abstract: Magnesium deficiency is known to produce myocardial fibrosis in different animal models, but the underlying mechanisms are unclear. However, circulating levels of pro-oxidant and mitogenic factors are reported to be elevated in a rodent model of acute magnesium deficiency, suggesting a role for humoral factors in the pathogenesis of the cardiovascular lesions. Probing the mechanism of cardiac fibrogenesis in magnesium deficiency, the present study furnished evidence that serum from magnesium-deficient rats has a more marked effect than serum from magnesium-sufficient rats on mitogenesis, net collagen production, and superoxide generation in cardiac fibroblasts from young adult rats. The enhanced mitogenic response was abolished by superoxide dismutase and N-acetyl cysteine, showing that it is mediated by superoxide anion. Further, a modest inhibitory effect of the neurokinin-1 receptor antagonist, spantide, suggested that factors acting via neurokinin-1 receptors may partly modulate cardiac fibroblast function in magnesium deficiency. The findings are consistent with the postulation that serum factors may activate cardiac fibroblasts via a superoxide-mediated mechanism and contribute to the fibrogenic response in the heart in magnesium deficiency. (C) 2001 Elsevier Science Inc.
URI: http://dx.doi.org/10.1016/S0891-5849(01)00656-6
http://www.ncbi.nlm.nih.gov/pubmed/11585706
http://dspace.sctimst.ac.in/jspui/handle/123456789/1117
Appears in Collections:Journal Articles

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