Please use this identifier to cite or link to this item: http://dspace.sctimst.ac.in/jspui/handle/123456789/214
Title: CASEIN AS A CARRIER MATRIX FOR 5-FLUOROURACIL - DRUG-RELEASE FROM MICROSPHERES, DRUG-PROTEIN CONJUGATES AND IN-VIVO DEGRADATION OF MICROSPHERES IN RAT MUSCLE
Authors: LATHA, MS
JAYAKRISHNAN, A
RATHINAM, K
MOHANTY, M
Keywords: Drug Delivery
Issue Date: 1994
Publisher: JOURNAL OF PHARMACY AND PHARMACOLOGY
Citation: JOURNAL OF PHARMACY AND PHARMACOLOGY. 46; 11; 858-862
Abstract: Glutaraldehyde cross-linked casein microspheres were loaded with 5-fluorouracil (5-FU) from concentrated aqueous solutions of the drug after the microspheres were synthesized and cleaned. In-vitro release of the drug was examined in phosphate buffer in the absence and in the presence of protease at 37 degrees C. Drug release data showed that only about 20% of the drug is released in the absence of protease even after 5 days, while digestion of the matrix with protease released the entrapped drug completely in about 24 h. A protein-drug conjugate was synthesized via carbamoyl linkage using 6-(5-FU-1-yl)hexyl isocyanate and the drug release was examined in phosphate buffer at 37 degrees C. Release from the protein-5-FU conjugate was slower compared with the release from microspheres in the presence of protease. Implantation of placebo microspheres of different cross-linking densities in the gluteal muscle of rats showed no adverse tissue reactions over a one-year period. Histopathological examination of the tissues containing injected microspheres suggested that the biological life of casein microspheres in muscle is about 6 months, which is three times that of cross-linked albumin microspheres.
URI: http://dspace.sctimst.ac.in/jspui/handle/123456789/214
Appears in Collections:Journal Articles

Files in This Item:
There are no files associated with this item.


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.