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Title: Risk of invasive cancer among women visually screened and colposcopy triaged by trained nurses in rural South India
Authors: Thulaseedharan, JV
Malila, N
Esmy, PO
Muwonge, R
Hakama, M
Sankaranarayanan, R
Keywords: Cervical cancer Cervical intraepithelial neoplasia Colposcopy Long-term risk Screening Visual inspection with acetic acid
Issue Date: Sep-2015
Publisher: Int J Gynaecol Obstet.
Citation: Thulaseedharan JV, Malila N, Esmy PO, Muwonge R, Hakama M, Sankaranarayanan R. Risk of invasive cancer among women visually screened and colposcopy triaged by trained nurses in rural South India. Int J Gynaecol Obstet. 2015;129(2):104-108
Abstract: Objective: To estimate the long-term risk of cervical cancer among women screened by visual inspection with acetic acid (VIA) and to evaluate the benefit of additional colposcopy triage in rural south India. Methods: A retrospective analysis was conducted among 31 343 women who had undergone VIA at Dindigul district, India between January 1, 2000, and August 5, 2003, as part of a randomized screening trial. Women with positive VIA test results were offered colposcopy triage by trained nurses. Cervical cancer incidence data during follow-up (January 1, 2000, to December 31, 2012) were obtained from a regional cancer registry. Results: Among 3021 screen-positive women free of cancer at baseline, 2974 women underwent colposcopy; colposcopic abnormalities suggestive of precancerous lesions were detected among 2792 of these women (93.9%). Compared with the women with negative VIA screening results, the hazard ratio (HR) of cervical cancer during follow-up among the VIA-positive women without colposcopic abnormalities was 6.5 (95% confidence interval [CI], 1.6–27.1). The risk was similar among VIA-positive women with colposcopic abnormalities but without histological confirmation (HR 5.2; 95% CI, 1.9–14.6). Conclusion: The high risk of cancer among women without colposcopic abnormalities who tested positive by VIA suggested that screening without triage is potentially effective.
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