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Title: Pathological fingerprinting of tissue observed through the window of fluorescence spectroscopy
Authors: Nazeer, SS
Jayasree, RS
Issue Date: Mar-2016
Publisher: Asian Journal of Physics.
Citation: Nazeer S S, Jayasree R S. Pathological fingerprinting of tissue observed through the window of fluorescence spectroscopy. Asian Journal of Physics. 2015;24(7):933-50
Abstract: There is a high demand for non invasive, non hazardous and fast techniques for the disease diagnose at its early onset which are affordable to common man. The background of the demand is the fact that an early stage diagnosis helps the physician or surgeon to intervene with effective therapeutic strategies to reduce morbidity and mortality. When considering the already prevailing techniques, each modality has its own merits and demerits. The advancement in the properties of light sources and supporting technologies and the potential of optical based techniques give a strong indication that optical pathology and non invasive optical diagnostics will replace the conventional techniques in next generation diagnostics. Spectral information are capable of providing biochemical and metabolic fingerprinting which is very essential for an early stage diagnosis, but lacks among the currently available techniques. Most useful spectroscopic techniques which have proven to be useful in diseases diagnosis are Raman spectroscopy, Infrared spectroscopy, Magnetic resonance spectroscopy and fluorescence spectroscopy. This review focuses on the fluorescence spectroscopy and the supporting statistical tools, the most economic and fast technique from the above list. Details on the instrumentation for in vitro and in vivo studies have also been reviewed. Case studies based on oral cavity disorders, brain tumor and liver abnormalities have been discussed in detail
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