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dc.contributor.authorKurian, MV-
dc.contributor.authorUmashankar, PR-
dc.contributor.authorSabareeswaran, A-
dc.contributor.authorShenoy, SJ-
dc.contributor.authorSubban, V-
dc.contributor.authorJoseph, MK-
dc.identifier.citationKurian M V, Umashankar P R, Sabareeswaran A, Shenoy S J, Subban V, Joseph M K. A new concept in the sewing rings of mechanical heart valves. Asian Cardiovasc Thorac Ann. 2012; 20(4):409-17.en_US
dc.description.abstractBACKGROUND: Valve-associated complications challenge the quality of life and longevity after heart valve replacement. Inappropriate healing may be a contributing factor. OBJECTIVE: To evaluate a new design mechanical heart valve in an animal model. METHODS AND RESULTS: The new valve was fabricated by substituting the sewing ring with an inbuilt suture ridge and an overlying fabric flap. It improved the effective orifice area. Animal experiments were performed on pigs to compare this valve with standard valve models. The animals were kept on dual antiplatelet drugs. Six of the 8 test animals survived the observation period of 140 days compared to 2 of the 6 controls. Among the test valves, one had thrombosis and 3 had significant tissue hyperplasia, whereas 5 control valves had thrombosis associated with significant tissue hyperplasia. Three test valves had paravalvular defects compared to none in the control group. Histology showed good tissue incorporation of the fabric flap of the test valves, whereas the control valves had tissue infiltration limited to the peripheral fabric layer of the sewing ring. CONCLUSION: The new valve has improved effective orifice area, and the animal study showed better survival, good healing, and a lower incidence of thrombosis and tissue hyperplasia.en_US
dc.publisher. Asian Cardiovasc Thorac Ann.en_US
dc.titleA new concept in the sewing rings of mechanical heart valvesen_US
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