Please use this identifier to cite or link to this item: http://dspace.sctimst.ac.in/jspui/handle/123456789/288
Title: Concepts and Controversies in Nonketotic Hyperglycemia-Induced Hemichorea: Further Evidence from Susceptibility-Weighted MR Imaging
Authors: Cherian, Ajith
Thomas, Bejoy
Baheti, Neeraj N.
Chemmanam, Thomas
Kesavadas, Chandrasekharan
Keywords: Radiology
Issue Date: 2009
Publisher: JOURNAL OF MAGNETIC RESONANCE IMAGING
Citation: JOURNAL OF MAGNETIC RESONANCE IMAGING. 29; 3; 699-703
Abstract: Hyperglycemia-induced hemichorea can show T1 hyperintensity of the contralateral striatum on MRI. This is thought to be due to petechial hemorrhages or gemistocytic astrocyte accumulation. This study explores the utility of susceptibility-weighted imaging (SWI) and diffusion-weighted imaging (DWI) in identifying the nature of these lesions. Three patients underwent MR imaging of the brain with SE T1, F SE T2. DWI, and SWI. T1 images showed hyperintensity predominantly involving the contralateral striatum, where mild (two cases) to moderate (one case) restricted diffusion (low apparent diffusion coefficient [ADC]) was detected on DWI. SWI demonstrated bilateral symmetrical hypointensities in the first two cases, suggesting age associated mineralization. In addition, increased susceptibility change (hypointensity) was also noted in the right putamen in the first and the third cases, suggesting paramagnetic mineral deposition. T1 hyperintensity may be from the protein hydration layer inside the cytoplasm of swollen gemistocytes appearing after an acute cerebral injury. These astrocytes also express metallothionein with zinc, which is thought to be the cause of asymmetric hypointensity of the posterior putamen on SWI. ADC values were thought to be useful for prognostication: however, they should be interpreted cautiously in the presence of susceptibility changes.
URI: http://dx.doi.org/10.1002/jmri.21672
http://www.ncbi.nlm.nih.gov/pubmed/19243044
http://dspace.sctimst.ac.in/jspui/handle/123456789/288
Appears in Collections:Journal Articles

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