Please use this identifier to cite or link to this item: http://dspace.sctimst.ac.in/jspui/handle/123456789/2917
Title: In vitro release study and antimicorbial property evaluation of ofloxacin loaded poly (2-hydroxyethyl methacrylate)/poly (caprolactone)/poly (ethylene glycol) hydrogel system for burn wound management
Authors: Rethikala, PK
Nair, RP
Krishnan, LK
Krishnan, VK
Keywords: Ofloxacin, Encapsulation efficiency, Hydrogel, Antimicrobial
Issue Date: Jan-2017
Publisher: Journal of Drug Delivery and therapeutics
Citation: Rethikala PK, Nair RP, Krishnan LK, Krishnan VK. In vitro release study and antimicorbial property evaluation of ofloxacin loaded poly (2-hydroxyethyl methacrylate)/poly (caprolactone)/poly (ethylene glycol) hydrogel system for burn wound management. Journal of Drug Delivery and therapeutics. 2017;7(1):13-20
Abstract: Monomer 2-hydroxy ethyl methacrylate containing small amounts of poly(caprolactone) and poly(ethylene glycol) incorporated with an antibiotic ofloxacin was polymerized by photo-polymerization technique using 2,4,6 trimethyl benzoyl diphenyl phosphine oxide (TPO) as photo-initiator. Encapsulation efficiency and in vitro drug release was studied using UV-visible spectroscopy. Swelling analysis was resorted to compare fluid uptake ability of hydrogel containing the drug with bare polymer. Zone of inhibition assay showed hydrogel containing 1% Ofloxacin to possess strong antimicrobial property Hemolysis assay demonstrated the hydrogel system to be non-hemolytic. Non-cytotoxic character of the hydrogel was confirmed using fibroblast cells. Cell adhesion studies showed non-attachment of fibroblasts to the polymer and improved cell proliferation simultaneously.
URI: http://dx.doi.org/10.22270/jddt.v6i6.1351
http://dspace.sctimst.ac.in/jspui/handle/123456789/2917
Appears in Collections:Journal Articles

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