Please use this identifier to cite or link to this item: http://dspace.sctimst.ac.in/jspui/handle/123456789/307
Title: Cost-effective utilization of single photon emission computed tomography (SPECT) in decision making for epilepsy surgery
Authors: Rathore, Chaturbhuj
Kesavadas, Chandrasekhar
Ajith, Joy
Sasikala, Achikanath
Sarma, Sankara P.
Radhakrishnan, Kurupath
Keywords: Radiology
Issue Date: 2011
Publisher: SEIZURE-EUROPEAN JOURNAL OF EPILEPSY
Citation: SEIZURE-EUROPEAN JOURNAL OF EPILEPSY. 20; 2; 107-114
Abstract: Purpose: To investigate the utility of single photon emission computed tomography (SPECT) without subtraction and MRI co-registration in decision making for epilepsy surgeryMethods: Patients with refractory epilepsy and nonlocalizing or discordant non-invasive data (clinical, long-term VEEG, and MRI) were subjected to interictal and ictal SPECT studies before planning invasive or surgical strategy. Final localization was based upon the preoperative information and seizure freedom after surgery. SPECT was considered to be useful for decision-making if it obviated the need for intracranial monitoring or influenced its planning.Results: 61 patients (mean age, 25.1 +/- 8.3 years) underwent SPECT studies between January 2004 and December 2008. Twenty-two patients had mesial temporal lobe epilepsy (MTLE), 13 had neocortical temporal lobe epilepsy (NTLE), and 26 had extratemporal lobe epilepsy (ETLE). As compared to ETLE, SPECT provided more localizing information (77.3% vs 46.2%, p = 0.006) and influenced the final decision-making (45.4% vs 11.53%, p = 0.005) in a significantly higher number of patients with MTLE. SPECT was particularly useful in patients with lesional TLE and nonlocalizing ictal data and in those with dual pathologies. SPECT did not provide any additional information in patients having either TLE or ETLE with normal MRI.Conclusions: SPECT is useful in a selected group of patients and unlikely to provide additional information in others. By restricting its use in patients who are likely to be benefited, a cost-effective utilization strategy can be employed in countries with limited resources. Due to the small number, these findings need to be validated in a larger group of patients. (C) 2010 British Epilepsy Association. Published by Elsevier Ltd. All rights reserved.
URI: http://dx.doi.org/10.1016/j.seizure.2010.10.033
http://www.ncbi.nlm.nih.gov/pubmed/21112798
http://dspace.sctimst.ac.in/jspui/handle/123456789/307
Appears in Collections:Journal Articles

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