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|Title:||Delivery of insulin from hydroxyapatite ceramic microspheres: Preliminary in vivo studies|
|Publisher:||JOURNAL OF BIOMEDICAL MATERIALS RESEARCH|
|Citation:||JOURNAL OF BIOMEDICAL MATERIALS RESEARCH. 61; 4; 660-662|
|Abstract:||The major limiting factor in utilizing protein drugs for sustained delivery is the lack of suitable delivery systems. Ceramic hydroxyapatite microspheres are biocompatible and utilized for the purification of proteins. As a preliminary study, we have investigated the possibility of using hydorxyapatite ceramic microspheres loaded with insulin as an implantable delivery system in rats. With this limited test, it was shown-that the loaded insulin was active and able to suppress the blood glucose level in normal rats. (C) 2002 Wiley Periodicals, Inc.|
|Appears in Collections:||Journal Articles|
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