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Title: Diagnostic utility of polymerase chain reaction and immunohistochemical techniques for the laboratory diagnosis of intracranial tuberculoma
Authors: Sumi, MG
Mathai, A
Sheela, R
Radhakrishnan, NS
Radhakrishnan, VV
Indhulekshmy, R
Mundayoor, S
Keywords: Immunology
Issue Date: 2001
Citation: CLINICAL NEUROPATHOLOGY. 20; 4; 176-180
Abstract: In an attempt to establish a tuberculous etiology, polymerase chain reaction (PCR) and immunohistochemical (IHC) methods were undertaken in formalin-fixed paraffin sections of ten surgical specimens of intracranial tuberculoma. The control group included an equal number of intracranial fungal granuloma. Both PCR and IHC methods did not yield false-positive results in fungal granuloma. PCR was found to be less sensitive (60%) than IHC method (80%) in this study. IHC method definitely possesses several operational advantages over PCR and is more suited to laboratories in developing countries for establishing a tuberculous etiology particularly in those patients in whom the conventional bacteriological methods did not confirm the diagnosis of tuberculoma.
Appears in Collections:Journal Articles

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