Please use this identifier to cite or link to this item: http://dspace.sctimst.ac.in/jspui/handle/123456789/56
Title: Acetylsalicylic acid loaded poly(vinyl alcohol) hemodialysis membranes: Effect of drug release on blood compatibility and permeability
Authors: Paul, W
Sharma, CP
Keywords: Drug Delivery
Issue Date: 1997
Publisher: JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
Citation: JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION. 8; 10; 755-764
Abstract: Membranes developed from poly(vinyl alcohol) (PVA) have superior permeability because of the highly hydrophilic character of PVA. However, its blood compatibility needs to be further improved. For this we have developed acetylsalicylic acid (ASA, aspirin) loaded PVA membranes. It seems that the slow release of aspirin from the membrane provides a surface concentration of aspirin sufficient for partially inhibiting platelet adhesion. PVA membrane with 531 mu g cm(-2) of ASA loaded, may be selected for hemodialysis applications. This may help to reduce the amount of heparin infused during hemodialysis, thereby reducing the side-effects associated with the systemic administration of heparin.
URI: http://dx.doi.org/10.1163/156856297X00290
http://dspace.sctimst.ac.in/jspui/handle/123456789/56
Appears in Collections:Journal Articles

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