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Title: Immunohistochemical demonstration of mycobacterial antigens in intracranial tuberculoma.
Authors: Radhakrishnan, V V
Mathai, A
Radhakrishnan, N S
Rout, D
Sehgal, S
Keywords: Pathology
Issue Date: 1991
Publisher: Indian journal of experimental biology
Citation: Indian journal of experimental biology. 29; 7; 641-4
Abstract: Mycobacterial antigens have been demonstrated immunohistochemically in the paraffin sections of 10 intracranial tuberculous granulomas and the results were compared with the detection of acid fast bacilli by conventional Ziehl-Neelsen method. In none of the 10 specimens, acid fast bacilli were demonstrated while mycobacterial antigens were characterised as diffusely staining granular brownish-pink material within the cytoplasm of giant cells and macrophages. In 14 specimens of granulomatous lesions due to non-tuberculous aetiology, immunohistochemical stains were negative for mycobacterial antigen. Thus demonstration of mycobacterial antigen will be not only useful in establishing mycobacterial aetiology of a caseating intracranial granuloma but also can be used as an alternative method to the conventional Ziehl-Neelsen method.
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