Please use this identifier to cite or link to this item: http://dspace.sctimst.ac.in/jspui/handle/123456789/616
Title: In vitro studies on the effect of physical cross-linking on the biological performance of aliphatic poly(urethane urea) for blood contact applications
Authors: Thomas, V
Kumari, TV
Jayabalan, M
Keywords: Biocompatibility
Issue Date: 2001
Publisher: BIOMACROMOLECULES
Citation: BIOMACROMOLECULES. 2; 2; 588-596
Abstract: The effect of physical cross-Linking in candidate cycloaliphatic and hydrophobic poly(urethane urea) (4,4'-methylenebis(cyclohexylisocyanate), H12MDI/hydroxy-terminated polybutadiene, HTPBD/hexamethylene-diamine, HDA) and poly(ether urethane urea)s (H12MDI/HTPBD-PTMG/HDA) on the in vitro calcification and blood-material interaction was studied. All the candidate poly(urethane urea)s and poly(ether urethane urea)s elicit acceptable hemolytic activity, cytocompatibility, calcification, and blood compatibility in vitro. The studies on blood-material interaction reveal that the present poly(urethane urea)s are superior to polystyrene microtiter plates which were used for the studies on blood-material interaction. The present investigation reveals the influence of physical cross-link density on biological interaction differently with poly(urethane urea) and poly(ether urethane urea)s. The higher the physical cross-link density in the poly(urethane urea)s, the higher the calcification and consumption of WBC in whole blood. On the other hand, the higher the physical cross-link density in the poly(ether urethane urea)s, the lesser the calcification and consumption of WBC in whole blood. However a reverse of the above trend has been observed with the platelet consumption in the poly(urethane urea)s and poly(ether urethane urea)s.
URI: http://dx.doi.org/10.1021/bm010044f
http://dspace.sctimst.ac.in/jspui/handle/123456789/616
Appears in Collections:Journal Articles

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