Please use this identifier to cite or link to this item: http://dspace.sctimst.ac.in/jspui/handle/123456789/710
Title: Long-Term Stability of Effects of Subthalamic Stimulation in Parkinson's Disease: Indian Experience
Authors: Kishore, Asha
Rao, Ravimohan
Krishnan, Syam
Panikar, Dilip
Sarma, Gangadhara
Sivasanakaran, Mathuranath Pavagada
Sarma, Sankara
Keywords: Neurology
Issue Date: 2010
Publisher: MOVEMENT DISORDERS
Citation: MOVEMENT DISORDERS. 25; 14; 2438-2444
Abstract: Reports of long-term effects of subthalamic (STN) stimulation for Parkinson's disease (PD) are few, mostly open-label evaluations and from Western centers. We used single-blind and open-label motor, cognitive and quality of life (QOL) evaluations to study the effects of bilateral STN stimulation in 45 patients over 5 years. Our patients showed a stable and substantial reduction in the cardinal signs of PD, motor fluctuations, and dyskinesias but less so for axial signs. The reduction in medications and the intensity of electrical stimulation needed also remained stable during follow up. Although the total QOL and its parkinsonism and social components showed sustained benefits till 5 years, the gains in emotional and systemic subsets were short lasting. Global scores for mood and cognition did not show significant worsening. Benefits of STN stimulation on the cardinal signs, motor complications, and QOL of advanced PD were substantial and sustained till 5 years. The initial benefits in axial motor signs and emotional and psychological aspects of QOL did not show similar stability. In general, the procedure had insignificant impact on cognition and mood. This is the first report of STN stimulation in Asian patients with PD. (C) 2010 Movement Disorder Society
URI: http://dx.doi.org/10.1002/mds.23269
http://www.ncbi.nlm.nih.gov/pubmed/20976738
http://dspace.sctimst.ac.in/jspui/handle/123456789/710
Appears in Collections:Journal Articles

Files in This Item:
There are no files associated with this item.


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.