Please use this identifier to cite or link to this item:
|Title:||L-type calcium channel blockers and EGTA enhance superoxide production in cardiac fibroblasts|
|Publisher:||JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY|
|Citation:||JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY. 33; 2; 373-377|
|Abstract:||Since the recognition of the importance of calcium ions to cardiac contractility, the effects of alterations in calcium homeostasis on cardiac myocyte function have attracted immense attention. However, the possibility that changes in extracellular calcium concentration or the administration of calcium channel blockers may exert significant effects on cardiac fibroblasts has not hitherto been explored. This communication presents evidence, for the first time, that EGTA, calcium-free incubation and L-type calcium channel blockers increase endogenous superoxide production in adult rat cardiac fibroblasts. A combination of ryanodine and EGTA was found to have an even greater effect. The observations indicate that extracellular calcium levels influence endogenous superoxide production in cardiac fibroblasts and support the postulation that myocardial fibroblasts may contribute to the cardiac effects of calcium channel blockers and alterations in extracellular calcium concentration. (C) 2001 Academic Press.|
|Appears in Collections:||Journal Articles|
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.