Please use this identifier to cite or link to this item: http://dspace.sctimst.ac.in/jspui/handle/123456789/744
Title: Microtox system, a new approach to the safety evaluation of medical devices
Authors: Rathinam, K
Mohanan, PV
Keywords: Biological Evaluation
Issue Date: 1998
Publisher: JOURNAL OF BIOMATERIALS APPLICATIONS
Citation: JOURNAL OF BIOMATERIALS APPLICATIONS. 13; 2; 166-171
Abstract: Medical devices of both intra- and extra-corporeal applications may contain leachable toxicants that warrant routine testing using internationally recognized/practiced protocols. An in vitro Microtox system comprising a selected bioluminescence strain of bacteria-Photobacterium phosphorium which emits light as an end product of its respiration, is used to screen out toxicants from biomaterials/devices. A Microtox system was standardized and validated in our laboratory conditions. Our experiences with extract of pyrogenic cardiotomy reservoir, blood filter and systemically toxic (in mice) Barium methacrylate (monomer), and CIBA epoxy polymer materials established a positive correlation with Microtox system. Hence, the Microtox system gives adequate evidence as an alternative in vitro method to evaluate the toxicity of biomaterials and medical devices.
URI: http://www.ncbi.nlm.nih.gov/pubmed/9777466
http://dspace.sctimst.ac.in/jspui/handle/123456789/744
Appears in Collections:Journal Articles

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