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http://dspace.sctimst.ac.in/jspui/handle/123456789/753
Title: | Modified polyacrylamide microspheres as immunosorbent |
Authors: | Panikkar, B Hari, PR Sharma, CP |
Keywords: | Biomaterials |
Issue Date: | 1997 |
Publisher: | ARTIFICIAL CELLS BLOOD SUBSTITUTES AND IMMOBILIZATION BIOTECHNOLOGY |
Citation: | ARTIFICIAL CELLS BLOOD SUBSTITUTES AND IMMOBILIZATION BIOTECHNOLOGY. 25; 6; 541-550 |
Abstract: | Extracorporeal immunoadsorption system has been used for the specific removal of immunologically active substances from the blood. In this study, an attempt is made to utilise polyacrylamide microspheres as a matrix for immunoadsorption. Phenyl alanine is coupled onto the polymer beads using glutaraldehyde. These modified beads exhibit a high binding affinity for gamma-globulin compared to bare beads. The surface modified ones showed selective adsorption of immunoglobulins of IgG class. The C-3 adsorption pattern is not altered significantly upon modification. Modified beads are found to be less hemolytic after modification. However, more studies are to be conducted for the development of a hemoperfusion column based on this modified matrix. |
URI: | http://dx.doi.org/10.3109/10731199709117451 http://dspace.sctimst.ac.in/jspui/handle/123456789/753 |
Appears in Collections: | Journal Articles |
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