Please use this identifier to cite or link to this item: http://dspace.sctimst.ac.in/jspui/handle/123456789/795
Title: Nimbolide retards tumor cell migration, invasion, and angiogenesis by downregulating MMP-2/9 expression via inhibiting ERK1/2 and reducing DNA-binding activity of NF-kappa B in colon cancer cells
Authors: Babykutty, Suboj
Priya, P. S.
Nandini, R. J.
Kumar, M. A. Suresh
Nair, Mangalam S.
Srinivas, Priya
Gopala, Srinivas
Keywords: Oncology
Issue Date: 2012
Publisher: MOLECULAR CARCINOGENESIS
Citation: MOLECULAR CARCINOGENESIS. 51; 6; 475-490
Abstract: Nimbolide, a plant-derived limonoid has been shown to exert its antiproliferative effects in various cell lines. We demonstrate that nimbolide effectively inhibited proliferation of WiDr colon cancer cells through inhibition of cyclin A leading to S phase arrest. It also caused activation of caspase-mediated apoptosis through the inhibition of ERK1/2 and activation of p38 and JNK1/2. Further nimbolide effectively retarded tumor cell migration and invasion through inhibition of metalloproteinase-2/9 (MMP-2/9) expression, both at the mRNA and protein level. It was also a strong inhibitor of VEGF expression, promoter activity, and in vitro angiogenesis. Finally, nimbolide suppressed the nuclear translocation of p65/p50 and DNA binding of NF-?B, which is an important transcription factor for controlling MMP-2/9 and VEGF gene expression. (C) 2011 Wiley Periodicals, Inc.
URI: http://dx.doi.org/10.1002/mc.20812
http://dspace.sctimst.ac.in/jspui/handle/123456789/795
Appears in Collections:Journal Articles

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