Please use this identifier to cite or link to this item: http://dspace.sctimst.ac.in/jspui/handle/123456789/889
Title: Polyvinyl alcohol-poly(caprolactone) semi IPN scaffold with implication for cartilage tissue engineering
Authors: Mohan, Neethu
Nair, Prabha D.
Keywords: Tissue Engineering
Issue Date: 2008
Publisher: JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
Citation: JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS. 84B; 2; 584-594
Abstract: Polycaprolactone is an FDA approved aliphatic polyester that is widely used as a scaffold for tissue engineering. It is hydrophobic and doesn't have any reactive functional groups on the polymer for further modification. Blending with other hydrophilic polymers like polyvinyl alcohol helps to generate a hybrid polymer with better properties. In this study we have been able to fabricate a novel porous 3D scaffold of Semi-IPN Poly (caprolactone)-Poly (vinyl alcohol). The Semi IPN is phase mixed and has synergistic properties of its constituent polymers. The hybrid scaffold is nontoxic and highly hydrophilic with greater percentage of swelling and is also amenable for further modification with bioactive peptides. Although porous with an open interconnected porous structure, the scaffold has adequate mechanical strength to withstand the load imparted by the cells during in vitro culture. Porcine chondrocytes seeded within the unmodified scaffolds secrete extra cellular matrix components revealing that the hybrid scaffold has immense potential for tissue engineering applications. (C) 2007 Wiley Periodicals, Inc.
URI: http://dx.doi.org/10.1002/jbm.b.30906
http://www.ncbi.nlm.nih.gov/pubmed/17618513
http://dspace.sctimst.ac.in/jspui/handle/123456789/889
Appears in Collections:Journal Articles

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