Please use this identifier to cite or link to this item: http://dspace.sctimst.ac.in/jspui/handle/123456789/90
Title: Aloe Emodin Induces G2/M Cell Cycle Arrest and Apoptosis via Activation of Caspase-6 in Human Colon Cancer Cells
Authors: Suboj, Priya
Babykutty, Suboj
Srinivas, Priya
Gopala, Srinivas
Keywords: Biochemistry
Issue Date: 2012
Publisher: PHARMACOLOGY
Citation: PHARMACOLOGY. 89; 40910; 91-98
Abstract: Aloe emodin (AE), a natural anthraquinone, is reported to have antiproliferative activity in various cancer cell lines. In this study, we analyzed the molecular mechanisms involved in the growth-inhibitory activity of this hydroxyanthraquinone in colon cancer cell, WiDr. In our observation AE inhibited cell proliferation by arresting the cell cycle at the G2/M phase and inhibiting cyclin B1. AE appreciably induced cell death specifically through the induction of apoptosis and by activating caspases 9/6. Apoptotic execution was found to be solely dependent on caspase-6 rather than caspase-3 or caspase-7. This is the first study indicating that the AE induces apoptosis specifically through the activation of caspase-6. Copyright (C) 2012 S. Karger AG, Basel
URI: http://dx.doi.org/10.1159/000335659
http://dspace.sctimst.ac.in/jspui/handle/123456789/90
Appears in Collections:Journal Articles

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