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dc.contributor.authorSreedharan, RM-
dc.contributor.authorMenon, AC-
dc.contributor.authorJames, JS-
dc.contributor.authorKesavadas, C-
dc.contributor.authorThomas, SV-
dc.identifier.citation57 ,3;291-297en_US
dc.description.abstractLanguage lateralization is unique to humans. Functional MRI (fMRI) and diffusion tensor imaging (DTI) enable the study of language areas and white matter fibers involved in language, respectively. The objective of this study was to correlate arcuate fasciculus (AF) laterality by diffusion tensor imaging with that by fMRI in preadolescent children which has not yet been reported. Ten children between 8 and 12 years were subjected to fMRI and DTI imaging using Siemens 1.5 T MRI. Two language fMRI paradigms-visual verb generation and word pair task-were used. Analysis was done using SPM8 software. In DTI, the fiber volume of the arcuate fasciculus (AFV) and fractional anisotropy (FA) was measured. The fMRI Laterality Index (fMRI-LI) and DTI Laterality Index (DTI-LI) were calculated and their correlation assessed using the Pearson Correlation Index. Of ten children, mean age 10.6 years, eight showed left lateralization while bilateral language lateralization was seen in two. AFV by DTI was more on the left side in seven of the eight children who had left lateralization by fMRI. DTI could not trace the AF in one child. Of the two with bilateral language lateralization on fMRI, one showed larger AFV on the right side while the other did not show any asymmetry. There was a significant correlation (p < 0.02) between fMRI-LI and DTI-LI. Group mean of AFV by DTI was higher on the left side (2659.89 +/- 654.75 mm(3)) as compared to the right (1824.11 +/- 582.81 mm(3)) (p < 0.01). Like fMRI, DTI also reveals language laterality in children with a high degree of correlation between the two imaging modalities.-
dc.subjectNeurosciences & Neurology; Radiology, Nuclear Medicine & Medical Imaging-
dc.titleArcuate fasciculus laterality by diffusion tensor imaging correlates with language laterality by functional MRI in preadolescent children-
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