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|Title:||Pro-fibrogenic effects of magnesium deficiency in the cardiovascular system|
|Citation:||MAGNESIUM RESEARCH. 15; 40972; 307-315|
|Abstract:||Magnesium deficiency is known to produce cardiovascular injury. A large body of experimental evidence supports the postulation that an immuno-inflammatory reaction and increased oxidative stress may damage the myocardium and vasculature in magnesium deficiency. Reparative/reactive fibrosis in response to the injury has, however, received little attention. Recent evidence from a rodent model of acute magnesium deficiency suggests that humoral factors may activate cardiac fibroblasts by a free radical-mediated mechanism and contribute to cardiac fibrogenesis. A similar mechanism may also promote cellular hyperplasia and increased matrix synthesis in the vasculature.|
|Appears in Collections:||Journal Articles|
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