Please use this identifier to cite or link to this item: http://dspace.sctimst.ac.in/jspui/handle/123456789/9364
Title: BIOAVAILABILITY OF THEOPHYLLINE FROM GLUTARALDEHYDE CROSS-LINKED CASEIN MICROSPHERES IN RABBITS FOLLOWING ORAL-ADMINISTRATION
Authors: LATHA, MS
RATHINAM, K
MOHANAN, PV
JAYAKRISHNAN, A
Keywords: Chemistry; Pharmacology & Pharmacy
Issue Date: 1995
Publisher: JOURNAL OF CONTROLLED RELEASE
Citation: 34 ,1;1-7
Abstract: Theophylline loaded bovine casein microspheres were prepared by the glutaraldehyde cross linking of an aqueous alkaline dispersion of the protein containing the drug in a non-aqueous dispersion medium. The cross-linking of the protein droplets was carried out via the organic phase by the addition of varying quantities of glutaraldehyde- saturated toluene. In vitro release of the drug was examined in simulated gastric fluid at 37 degrees C from spheres having three different cross-linking densities. The bioavailability of theophylline released from the microspheres of different cross-linking densities was studied in rabbits following single oral administration. Microspheres with higher cross-linking densities were found to sustain theophylline release even up to 24 h. The peak serum concentrations of such preparations were well within therapeutic limits. Determinations of in vitro/in vivo correlation based on the data showed that a fairly good relationship exists between in vitro and in vivo release. The study demonstrated the potential of cross-linked milk protein as a matrix for sustained release oral preparations.
URI: 10.1016/0168-3659(94)00088-C
http://dspace.sctimst.ac.in/jspui/handle/123456789/9364
Appears in Collections:Journal Articles

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