Please use this identifier to cite or link to this item: http://dspace.sctimst.ac.in/jspui/handle/123456789/94
Title: Alterations in collagen metabolism and increased fibroproliferation in the heart in cerium-treated rats: implications for the pathogenesis of endomyocardial fibrosis.
Authors: Prakash Kumar, B
Shivakumar, K
Keywords: Biochemistry
Issue Date: 1998
Publisher: Biological trace element research
Citation: Biological trace element research. 63; 1; 73-9
Abstract: Cerium (Ce), a rare earth element, has been postulated to play a role in the pathogenesis of tropical endomyocardial fibrosis (EMF). Investigations carried out recently in pursuance of the postulation furnished histological evidence of EMF and increased cardiac collagen content in rats on prolonged administration of Ce. The present study was undertaken to understand the molecular basis of myocardial injury and fibrosis produced by the element. This article presents evidence of increased lipid peroxidation and elevated rates of fibroblast proliferation and collagen deposition in the heart in Ce-treated rats. It is suggested that the element may trigger a wound-healing response in the cardiac tissue leading to cardiac fibrosis.
URI: http://dspace.sctimst.ac.in/jspui/handle/123456789/94
Appears in Collections:Journal Articles

Files in This Item:
There are no files associated with this item.


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.