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|Title:||Cell-mimetic coatings for immune spheres|
|Keywords:||Biophysics; Chemistry; Materials Science|
|Publisher:||COLLOIDS AND SURFACES B-BIOINTERFACES|
|Abstract:||Extrinsically induced or engineered cells are providing new therapeutic means in emerging fields such as cell therapeutics, immunomodulation and regenerative medicine. We are demonstrating a spatial induction method using lipid coatings, which can change signal presentation strength from material surface to adherent macrophage cells, that induce early cell-cell interaction leading to organotypic morphology. For that, we have developed a cell mimetic lipid coating with a rafts size to the order of transmembrane proteins (<10 nm) with enhanced lateral elastic properties. Such surface coatings are capable of reducing adherent macrophage spreading, while enabling early induction of cell-cell interaction to form organotypic macrophage colonies or "spheres" (M-spheres). (C) 2014 Elsevier B.V. All rights reserved.|
|Appears in Collections:||Journal Articles|
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