Please use this identifier to cite or link to this item:
http://dspace.sctimst.ac.in/jspui/handle/123456789/9424
Title: | Cell-mimetic coatings for immune spheres |
Authors: | Kaladhar, K Renz, H Sharma, CP |
Keywords: | Biophysics; Chemistry; Materials Science |
Issue Date: | 2014 |
Publisher: | COLLOIDS AND SURFACES B-BIOINTERFACES |
Citation: | 123 ,;845-851 |
Abstract: | Extrinsically induced or engineered cells are providing new therapeutic means in emerging fields such as cell therapeutics, immunomodulation and regenerative medicine. We are demonstrating a spatial induction method using lipid coatings, which can change signal presentation strength from material surface to adherent macrophage cells, that induce early cell-cell interaction leading to organotypic morphology. For that, we have developed a cell mimetic lipid coating with a rafts size to the order of transmembrane proteins (<10 nm) with enhanced lateral elastic properties. Such surface coatings are capable of reducing adherent macrophage spreading, while enabling early induction of cell-cell interaction to form organotypic macrophage colonies or "spheres" (M-spheres). (C) 2014 Elsevier B.V. All rights reserved. |
URI: | 10.1016/j.colsurfb.2014.10.029 http://dspace.sctimst.ac.in/jspui/handle/123456789/9424 |
Appears in Collections: | Journal Articles |
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.