Please use this identifier to cite or link to this item: http://dspace.sctimst.ac.in/jspui/handle/123456789/966
Title: RAPID DIAGNOSIS OF TUBERCULOUS MENINGITIS WITH A DOT ENZYME-IMMUNOASSAY TO DETECT ANTIBODY IN CEREBROSPINAL-FLUID
Authors: MATHAI, A
RADHAKRISHNAN, VV
THOMAS, M
Keywords: Immunology
Issue Date: 1991
Publisher: EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES
Citation: EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES. 10; 5; 440-443
Abstract: A simple dot enzyme immunoassay (Dot-EIA) was carried out to detect antibody to Mycobacterium tuberculosis antigen 5 in cerebrospinal fluid (CSF) specimens from 40 patients with a clinical diagnosis of tuberculous meningitis (TBM). The assay gave a positive reaction in all ten patients with culture proven TBM. In 30 culture negative patients with TBM, the assay was positive at a titre of 1:16 in 18 patients. In 40 patients with non-tuberculous neurological diseases (control group) the assay was negative at a titre of 1:16. The Dot-EIA had an overall sensitivity of 70% and a specificity of 100% in the diagnosis of TBM. This assay could be used as a rapid screening test to establish the diagnosis of TBM, particularly in patients in whom bacteriological investigations for Mycobacterium tuberculosis in CSF specimens are negative.
URI: http://dx.doi.org/10.1007/BF01968025
http://dspace.sctimst.ac.in/jspui/handle/123456789/966
Appears in Collections:Journal Articles

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