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Title: Failure to find association between febrile seizures and SCN1A rs3812718 polymorphism in south Indian patients with mesial temporal lobe epilepsy and hippocampal sclerosis
Authors: Balan, S
Vellichirammal, NN
Banerjee, M
Radhakrishnan, K
Keywords: Neurosciences & Neurology
Issue Date: 2012
Citation: 101 ,3;288-292
Abstract: We compared the allele and genotype frequencies of SCN1A SNP rs3812718 between patients with MTLE-HS of south Indian ancestry with and without febrile seizures (FS) and with ethnically matched controls. While we observed no significant difference in allele and genotype frequencies of rs3812718 between MTLE-HS patients with and without FS, A allele and AA genotype were overrepresented in MTLE-HS patients when compared to controls. We conclude that in the population studied, although rs3812718 polymorphism increases the susceptibility to MTLE-HS, this is not by increasing the susceptibility to FS. (C) 2012 Elsevier B.V. All rights reserved.
URI: 10.1016/j.eplepsyres.2012.04.009
Appears in Collections:Journal Articles

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