Please use this identifier to cite or link to this item:
Title: Galactosylated pullulan-curcumin conjugate micelles for site specific anticancer activity to hepatocarcinoma cells
Authors: Sarika, PR
James, NR
Nishna, N
Kumar, PRA
Raj, DK
Keywords: Biophysics; Chemistry; Materials Science
Issue Date: 2015
Citation: 133 ,;347-355
Abstract: Galactosylated pullulan curcumin conjugate (LANH(2)-Pu Aid-Cur SA) is developed for target specific delivery of curcumin to hepatocarcinoma cells by five step synthetic strategy, which includes oxidation of pullulan (Pu Ald), introduction of amino group to the targeting ligand (LANH(2)), grafting of the LANH(2) to Pu Aid, modification of curcumin (Cur SA) and conjugation of Cur SA to pullulan. Nongalactosylated pullulan curcumin conjugate (Pu-Cur SA) is also prepared to compare the enhancement in cytotoxicity offered by the targeting group. Both LANH(2)-Pu Aid-Cur SA and Pu-Cur SA conjugates could self assemble to micelle in water with hydrodynamic diameters of 355 +/- 9 nm and 363 +/- 10 nm, respectively. Both conjugates show spherical morphology and enhance stability of curcumin in physiological pH. Compared to Pu-Cur SA, LANH(2)-Pu Aid-Cur SA exhibits higher toxicity and internalization towards HepG2 cells. This indicates the enhanced uptake of LANH(2)-Pu Ald-Cur SA conjugate via ASGPR (asialoglycoprotein receptor) mediated endocytosis into HepG2 cells. (C) 2015 Elsevier B.V. All rights reserved.
URI: 10.1016/j.colsurfb.2015.06.020
Appears in Collections:Journal Articles

Files in This Item:
There are no files associated with this item.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.