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Title: Inherently X-ray opaque polyurethane microspheres for biomedical applications
Authors: Kiran, S
Sunny, MC
Joseph, R
Keywords: Materials Science; Polymer Science
Issue Date: 2017
Citation: 66 ,5;213-220
Abstract: In this work synthesis and characterization of inherently X-ray opaque, nonresorbable polyurethane microspheres with well-calibrated particles in a defined range of sizes suitable for embolization is reported. In order to impart X-ray opacity to the polyurethane, a bifunctional monomer, namely, 4,4-isopropylidenediphenol (BPA) was iodinated and this iodinated compound was used as one of the monomers during polyurethane synthesis. The resultant X-ray opaque polyurethane was converted into microspheres using an oil-in-water emulsion and solvent evaporation technique. Microspheres obtained had diameters in the range of 200-500 mu m, were noncytotoxic and free from X-ray attenuating additives. In vivo X-ray fluoroscopic imaging carried out in a rabbit cadaver model showed that these microspheres were sufficiently X-ray opaque to be visualized under fluoroscopic conditions. [GRAPHICS] .
URI: 10.1080/00914037.2016.1201764
Appears in Collections:Journal Articles

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