Joseph, XAkhil, VArathi, AMohanan, PV2022-04-042022-04-042022-05Joseph X, Akhil V , Arathi A, Mohanan PV. Nanobiomaterials in support of drug delivery related issues. Materials Science & Engineering B. 2022 May:115680https://doi.org/10.1016/j.mseb.2022.115680https://dspace.sctimst.ac.in/handle/123456789/11197Nanobiomaterials have been widely accepted as potential drug delivery agents over the past decade. A wide variety of materials have been utilized as drug delivery carriers for various diseases like Cancer, Alzheimer's etc. Being the leading cause of death worldwide, effective drug delivery to cancer cells by using nanomaterials has become the most fascinating and dynamic regions of research. The decreased size of these materials increased permeability through physiological barriers, and increased cell to cell interactions are the properties that are highly suitable for drug delivery applications. Biocompatibility and biodegradability are added advantages of using nano biomaterials as drug delivery systems. However, to transfer the nanobiomaterials for advanced clinical applications, a detailed study should be established considering the interactions of these nanobiomaterials with the physiological environment. Moreover, the need for extensive toxicity studies will open up a new window for the effective translation of these materials into clinical drug delivery carriers. The integration of nanomedicine and drug delivery system framework is unquestionably the pattern that will stay in the field of innovative work for quite a long time. Herein, we highlight the challenges of nanobiomaterials related to drug delivery and the possible strategies utilized to overcome the drug delivery-related issues.Nanobiomaterials; Drug delivery; Toxicity; Controlled release; Surface modificationArticle