Suresh, KThomas, SVSuresh, G2017-03-102017-03-10201114 ,4;287-29010.4103/0972-2327.91951https://dspace.sctimst.ac.in/handle/123456789/9559Statistical analysis is an essential technique that enables a medical research practitioner to draw meaningful inference from their data analysis. Improper application of study design and data analysis may render insufficient and improper results and conclusion. Converting a medical problem into a statistical hypothesis with appropriate methodological and logical design and then back-translating the statistical results into relevant medical knowledge is a real challenge. This article explains various sampling methods that can be appropriately used in medical research with different scenarios and challenges.Neurosciences & Neurology