Thomas, VinoyJayabalan, Muthu2012-12-042012-12-042009JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A. 89A; 1; 192-205http://dx.doi.org/10.1002/jbm.a.31937https://dspace.sctimst.ac.in/handle/123456789/25Development of new generation high flex life polyurethane urea (HFL18-PU) with appropriate elastic modulus, biocompatibility, blood compatibility, resistant to calcification, and biodurability for the long-term use as cardiac device is still a challenge. This study reports the development of a fully aliphatic, ether-free physically cross-linked and low elastic modulus (6.841 +/- 0.27 MPa) polyurethane urea having hi vivo biostability, in vivo biocompatibility and high flex-life (721 +/- 30 million cycles) that can satisfy the requirements for the fabrication of tri-leaflet heart valve. (c) 2008 Wiley Periodicals, Inc. J Biomed Mater Res 89A: 192-205, 2009Biomaterials